Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy. Issue 5 (17th January 2023)

• Record Type: Journal Article
• Authors: Fabozzi, Antonio; Della Sala, Francesca; di Gennaro, Mario; Barretta, Marco; Longobardo, Gennaro; Solimando, Nicola; Pagliuca, Maurizio; Borzacchiello, Assunta
• Is Part Of: Lab on a chip. Volume 23:Issue 5(2023)
• Page Start: 1389
• Page End: 1409
• Publication Date: 2023-01-17
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/d2lc00933a
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : Nanoparticle systems are functional carriers that can be used in the cancer therapy field for the delivery of a variety of hydrophobic and/or hydrophilic drugs. Abstract : Nanoparticle systems are functional carriers that can be used in the cancer therapy field for the delivery of a variety of hydrophobic and/or hydrophilic drugs. Recently, the advent of microfluidic platforms represents an advanced approach to the development of new nanoparticle-based drug delivery systems. Particularly, microfluidics can simplify the design of new nanoparticle-based systems with tunable physicochemical properties such as size, size distribution and morphology, ensuring high batch-to-batch reproducibility and consequently, an enhanced therapeutic effect in vitro and in vivo . In this perspective, we present accurate state-of-the-art microfluidic platforms focusing on the fabrication of polymer-based, lipid-based, lipid/polymer-based, inorganic-based and metal-based nanoparticles for biomedical applications.