Catalyst-free electrochemical trifluoromethylation of coumarins using CF3SO2NHNHBoc as the CF3 source. Issue 9 (14th February 2023) - Cen, Nannan
Abstract : An efficient electrochemical trifluoromethylation of coumarins using CF3 SO2 NHNHBoc as the source of the trifluoromethyl group was developed. Abstract : An efficient electrochemical trifluoromethylation of coumarins using CF3 SO2 NHNHBoc as the source of the trifluoromethyl group was developed. Under catalyst-free and external oxidant-free electrolysis conditions, a range of 3-trifluoromethyl coumarins were obtained in moderate to good yields. The method could be easily scaled up with moderate efficiency.