An evidence-based review of recent advances in therapy for heart failure with reduced ejection fraction (HFrEF). Issue 1094 (5th October 2016)

• Record Type: Journal Article
• Authors: Raj, Leah; Adhyaru, Bhavin
• Is Part Of: Postgraduate medical journal. Volume 92:Issue 1094(2016)
• Page Start: 726
• Page End: 734
• Publication Date: 2016-10-05
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/postgradmedj-2016-134378
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract: An estimated 5.1 million Americans have chronic heart failure and this is expected to increase 25% by 2030. Heart failure is a clinical syndrome that evolves from either functional or structural changes to the ventricles that lead to filling or ejection abnormalities. Thus far, pharmacotherapy has been show to be beneficial in patients only with reduced ejection fraction; however, new therapies have been developed in hopes of reducing the burden of heart failure. In this review, we will discuss current pharmacotherapies recommended in American College of Cardiology/American Heart Association guidelines, the evidence behind these recommendations as well as new and emerging therapies that have been developed.