Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms. Issue 3 (27th May 2021)

• Record Type: Journal Article
• Authors: Zhang, Zhiyu; Deng, Mengting; Hao, Meng; Tang, Jianxia
• Is Part Of: Journal of leukocyte biology. Volume 110:Issue 3(2021)
• Page Start: 565
• Page End: 576
• Publication Date: 2021-05-27
• Subjects: bacterial infections -- homeostasis -- host-pathogen interactions -- immunity -- mesenchymal stromal cells -- stem cell niche; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.4MR0421-750R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Periodontitis is characterized by the periodontium's pathologic destruction due to the host's overwhelmed inflammation to the dental plaque. The bacterial infections and subsequent host immune responses have shaped a distinct microenvironment, which generally affects resident periodontal ligament stem cells (PDLSCs). Interestingly, recent studies have revealed that impaired PDLSCs may also contribute to the disturbance of periodontal homeostasis. The putative vicious circle underlying the interesting "positive feedback" of PDLSCs in the periodontitis niche remains a hot research topic, whereas the inseparable interactions between resident PDLSCs and the periodontitis niche are still not fully understood. This review provides a microscopic view on the periodontitis progression, especially the quick but delicate immune responses to oral dysbacterial infections. We also summarize the interesting crosstalk of the resident PDLSCs with their surrounding periodontitis niche and potential mechanisms. Particularly, the microenvironment reduces the osteogenic properties of resident PDLSCs, which are closely related to their reparative activity. Reciprocally, these impaired PDLSCs may disrupt the microenvironment by aggravating the host immune responses, promoting aberrant angiogenesis, and facilitating the osteoclastic activity. We further recommend that more in-depth studies are required to elucidate the interactions of PDLSCs with the periodontal microenvironment and provide novel interventions for periodontitis. Graphical Abstract: Review of the interactions and potential mechanisms between resident PDLSCs and periodontitis niche for maintaining periodontal homeostasis.