Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases. Issue 1 (10th November 2021)

• Record Type: Journal Article
• Authors: Babuta, Mrigya; Szabo, Gyongyi
• Is Part Of: Journal of leukocyte biology. Volume 111:Issue 1(2022)
• Page Start: 75
• Page End: 92
• Publication Date: 2021-11-10
• Subjects: biomarkers -- exosomes -- extracellular vesicles -- inflammation -- liver damage -- microRNA; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.3MIR0321-156R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Extracellular vesicles (EVs) are heterogeneous nanometer-ranged particles that are released by cells under both normal and pathological conditions. EV cargo comprises of DNA, protein, lipids cargo, metabolites, mRNA, and non-coding RNA that can modulate the immune system by altering inflammatory response. EV associated miRNAs contribute to the pathobiology of alcoholic liver disease, non-alcoholic liver disease, viral hepatitis, acetaminophen-induced liver injury, fibrosis, and hepatocellular carcinoma. In context of liver diseases, EVs, via their cargo, alter the inflammatory response by communicating with different cell types within the liver and between liver and other organs. Here, the role of EVs and its associated miRNA in inter-cellular communication in different liver disease and as a potential biomarker and therapeutic target is reviewed. Graphical Abstract: Extracellular vesicle-associated miRNAs alter the immune response by inter-cellular and inter-organ communication and thereby contribute to the pathobiology of various liver diseases.