Immune checkpoint inhibitors in the management of malignancies in transplant recipients. Issue 1118 (13th November 2018)

• Record Type: Journal Article
• Authors: Regalla, Dileep Kumar Reddy; Williams, Grant R; Paluri, Ravi kumar
• Is Part Of: Postgraduate medical journal. Volume 94:Issue 1118(2018)
• Page Start: 704
• Page End: 708
• Publication Date: 2018-11-13
• Subjects: immune checkpoint inhibitors -- solid organ transplant -- malignancy -- monoclonal antibodies -- CTLA-4 -- PD-1; Medicine -- Periodicals; 610
• DOI: 10.1136/postgradmedj-2018-136081
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract: Cancer immunotherapy, an area of active research, has thus far yielded several exciting breakthroughs in cancer treatment strategies. So far, immune checkpoint inhibitors have been the most promising method of cancer immunotherapy. CTLA-4, PD-1 and PD-L1 are the immune checkpoint molecules against which monoclonal antibodies act against and revolutionised the treatment of several malignancies. However, it is still unclear whether using these monoclonal antibodies in patients with malignancy and a history of transplant is as beneficial as in patients without a history of transplantation. The reason being, with the therapeutic benefit, also comes the inherent disadvantage of transplant rejection because of the activation of T-cells against donor antigens. So, transplant-related complications limit the usage of the checkpoint blockade therapy to treat malignancies. Here, we review the data published in this context and suggest optimal approaches to using the currently available repertoire of immunotherapies.