Potential role of cyclophilin A in regulating cytokine secretion. Issue 4 (1st October 2017)

• Record Type: Journal Article
• Authors: Dawar, Farman Ullah; Xiong, Yang; Khattak, Muhammad Nasir Khan; Li, Jun; Lin, Li; Mei, Jie
• Is Part Of: Journal of leukocyte biology. Volume 102:Issue 4(2017)
• Page Start: 989
• Page End: 992
• Publication Date: 2017-10-01
• Subjects: CD147 -- inflammation -- diseases -- mechanism; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.3RU0317-090RR
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on the role of cyclophilin A in mediation of cytokine secretion, and its potential as a therapeutic target in inflammatory diseases. Abstract: Cyclophilin A (CypA), a peptidylprolyl cis - trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.