Role of the reprogramming factor KLF4 in blood formation. Issue 5 (23rd February 2016)

• Record Type: Journal Article
• Authors: Park, Chun Shik; Shen, Ye; Lewis, Andrew; Lacorazza, H Daniel
• Is Part Of: Journal of leukocyte biology. Volume 99:Issue 5(2016)
• Page Start: 673
• Page End: 685
• Publication Date: 2016-02-23
• Subjects: transcription factor -- hematopoiesis -- gene regulation -- lymphocytes -- myeloid cells; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.1RU1215-539R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on the role of KLF4 in myeloid and lymphoid blood cell development and function. Abstract: Krüppel-like factor 4 is a zinc finger protein with dual functions that can act as a transcriptional activator and repressor of genes involved in cell proliferation, differentiation, and apoptosis. Although most studies have focused on terminally differentiated epithelial cells, evidence suggests that Krüppel-like factor 4 regulates the development and function of the myeloid and lymphoid blood lineages. The ability of Krüppel-like factor 4 to dedifferentiate from somatic cells into pluripotent stem cells in cooperation with other reprogramming factors suggests its potential function in the preservation of tissue-specific stem cells. Additionally, emerging interest in the redifferentiation of induced pluripotent stem cells into blood cells to correct hematologic deficiencies and malignancies warrants further studies on the role of Krüppel-like factor 4 in steady-state blood formation.