The liver as a nursery for leukocytes. Issue 3 (20th May 2019)

• Record Type: Journal Article
• Authors: Mafra, Kassiana; Nakagaki, Brenda Naemi; Castro Oliveira, Hortência Maciel; Rezende, Rafael Machado; Antunes, Maísa Mota; Menezes, Gustavo Batista
• Is Part Of: Journal of leukocyte biology. Volume 106:Issue 3(2019)
• Page Start: 687
• Page End: 693
• Publication Date: 2019-05-20
• Subjects: liver -- hematopoiesis -- newborn -- immune system -- metabolism -- in vivo imaging -- immunity; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.MR1118-455R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occur in the bone marrow, it is well known that this process—called hematopoiesis—started in the embryonic life in different sites, including the yolk sac, placenta, and the liver. In this review, we will discuss how the liver acts as a pivotal site for leukocyte maturation during the embryo phase, and also how the most frequent liver-resident immune cell populations—namely Kupffer cells, dendritic cells, and lymphocytes—play a vital role in both tolerance and inflammatory responses to antigens from food, microbiota, and pathogens. Graphical Abstract: Review on how the liver immune cell populations play a vital role in both tolerance and inflammatory responses to antigens from food, microbiota and pathogens.