IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression. Issue 6 (22nd February 2018)

• Record Type: Journal Article
• Authors: Aqbi, Hussein F; Wallace, Matthew; Sappal, Samay; Payne, Kyle K; Manjili, Masoud H
• Is Part Of: Journal of leukocyte biology. Volume 103:Issue 6(2018)
• Page Start: 1219
• Page End: 1223
• Publication Date: 2018-02-22
• Subjects: IFN-γ -- immunotherapy -- tumor dormancy -- tumor immunoediting; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.5MIR0917-351R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Tumor immunoediting consisting of three phases of elimination, equilibrium or dormancy, and escape has been supported by preclinical and clinical data. A comprehensive understanding of the molecular mechanisms by which antitumor immune responses regulate these three phases are important for developing highly tailored immunotherapeutics that can control cancer. To this end, IFN-γ produced by Th1 cells, cytotoxic T cells, NK cells, and NKT cells is a pleiotropic cytokine that is involved in all three phases of tumor immunoediting, as well as during inflammation-mediated tumorigenesis processes. This essay presents a review of literature and suggests that overcoming tumor escape is feasible by driving tumor cells into a state of quiescent but not indolent dormancy in order for IFN-γ-producing tumor-specific T cells to prevent tumor relapse. Abstract : Review on the mechanisms by which IFN-gamma manifests paradoxical functions of relevance to developing highly tailored immunotherapeutics for cancer patients.