Association of pulse pressure with all-cause mortality in young adults. Issue 1138 (28th November 2019)

• Record Type: Journal Article
• Authors: LI, Jie; Huang, Jia-Yi; Lo, Kenneth; Zhang, Bin; Huang, Yu-Qing; Feng, Ying Qing
• Is Part Of: Postgraduate medical journal. Volume 96:Issue 1138(2020)
• Page Start: 461
• Page End: 466
• Publication Date: 2019-11-28
• Subjects: pulse pressure -- blood pressure -- mortality -- young adults -- NHANES; Medicine -- Periodicals; 610
• DOI: 10.1136/postgradmedj-2019-137070
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract: Background: Pulse blood pressure was significantly associated with all-cause mortality in middle-aged and elderly populations, but less evidence was known in young adults. Objective: To assess the association of pulse pressure (PP) with all-cause mortality in young adults. Methods: This cohort from the 1999–2006 National Health and Nutrition Examination Survey included adults aged 18–40 years. All included participants were followed up until the date of death or 31 December 2015. PP was categorised into three groups: <50, 50~60, ≥60 mm Hg. Cox proportional hazards models and subgroup analysis were performed to estimate the adjusted HRs and 95% CIs for all-cause mortality. Results: After applying the exclusion criteria, 8356 participants (median age 26.63±7.01 years, 4598 women (55.03%)) were included, of which 265 (3.17%) have died during a median follow-up duration of 152.96±30.45 months. When treating PP as a continuous variable, multivariate Cox analysis showed that PP was an independent risk factor for all-cause mortality (HR 1.94, 95% CI 1.02 to 3.69; p=0.0422). When using PP<50 mm Hg as referent, from the 50~60 mm Hg to the ≥60 mm Hg group, the risks of all-cause mortality for participants with PP ranging 50–60 mm Hg or ≥60 mm Hg were 0.93 (95% CI 0.42 to 2.04) and 1.15 (95% CI 0.32 to 4.07) (P for tend was 0.959). Subgroup analysis showed that PP (HR 2.00, 95% CI 1.05 to 3.82; p=0.0360) was associated with all-cause mortality among non-hypertensive participants. Conclusion: Among young adults, higher PP was significantly associated with an increased risk of all-cause mortality, particularly among those without hypertension.