The interplay between depression and tuberculosis. Issue 3 (28th June 2019)

• Record Type: Journal Article
• Authors: Zhang, Kehong; Wang, Xin; Tu, Jie; Rong, Han; Werz, Oliver; Chen, Xinchun
• Is Part Of: Journal of leukocyte biology. Volume 106:Issue 3(2019)
• Page Start: 749
• Page End: 757
• Publication Date: 2019-06-28
• Subjects: depression -- tuberculosis -- Mycobacterium tuberculosis -- inflammation -- lipid metabolism -- antidepressant therapy; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.MR0119-023R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Depression is a major mental health condition and is expected be the most debilitating and widespread health disorder by 2030. Tuberculosis (TB) is also a leading cause of morbidity and mortality worldwide and interestingly, is a common comorbidity of depression. As such, much attention has been paid to the association between these 2 pathologies. Based on clinical reports, the association between TB and depression seems to be bidirectional, with a substantial overlap in symptoms between the 2 conditions. TB infection or reactivation may precipitate depression, likely as a consequence of the host's inflammatory response and/or dysregulation of the hypothalamic–pituitary–adrenal axis. Nevertheless, few studies have considered whether patients with depression are at a higher risk for TB. In this review, we discuss the hypotheses on the association between depression and TB, highlighting the immuno-inflammatory response and lipid metabolism as potential mechanisms. Improving our understanding of the interplay between these 2 disorders should help guide TB clinical care and prevention both in patients with comorbid depression and in the general population. Graphical Abstract: Review on the association between depression and tuberculosis, includes a potential mechanism underlying depression's role in increasing the risk for tuberculosis.