Regulation of IgE by T follicular helper cells. Issue 3 (22nd January 2020)

• Record Type: Journal Article
• Authors: Gowthaman, Uthaman; Chen, Jennifer S.; Eisenbarth, Stephanie C.
• Is Part Of: Journal of leukocyte biology. Volume 107:Issue 3(2020)
• Page Start: 409
• Page End: 418
• Publication Date: 2020-01-22
• Subjects: Allergy -- Anaphylaxis -- IgE -- Tfh cells -- Th2 cells; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.3RI1219-425R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one of the hallmarks of anaphylaxis-inducing IgE molecules is their high affinity for allergen, and the cellular pathway to high-affinity IgE is typically through sequential switching of IgG B cells. Further, in contrast to the previously held paradigm that a subset of CD4 + T cells called Th2 cells promotes IgE responses, recent studies suggest that T follicular helper cells are crucial for inducing anaphylactic IgE. Here we discuss recent studies that have enabled us to understand the nature, induction, and regulation of this enigmatic antibody isotype in allergic sensitization.