Tumor formation and antitumor immunity; the overlooked significance of histamine. Issue 2 (5th June 2014)

• Record Type: Journal Article
• Authors: Falus, Andras; Gilicze, Anna
• Is Part Of: Journal of leukocyte biology. Volume 96:Issue 2(2014)
• Page Start: 225
• Page End: 231
• Publication Date: 2014-06-05
• Subjects: cancer -- biogenic amine -- regulation -- immune response; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.3RI0413-217RR
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on histamine as a relevant player in the generation and maintenance of tumors and anti-tumor responses. Abstract: HA is a biogenic amine, widely distributed throughout the body. Given the observations that HA, the decarboxylated amino acid histidine, can be induced and made available in an unstored, diffusible form in tissues undergoing rapid growth (such as tumors and regenerating tissues), it could have a role in antitumor response beyond the well-studied inflammatory and allergic responses.