Quantitative proteomic analyses in blood: A window to human health and disease. Issue 3 (22nd July 2019)

• Record Type: Journal Article
• Authors: Whittaker, Kelly; Burgess, Rob; Jones, Valerie; Yang, Yanqing; Zhou, Weifan; Luo, Shuhong; Wilson, Jarad; Huang, Ruo-Pan
• Is Part Of: Journal of leukocyte biology. Volume 106:Issue 3(2019)
• Page Start: 759
• Page End: 775
• Publication Date: 2019-07-22
• Subjects: proteomics -- cytokine -- Parkinson's Disease -- obesity -- prostate cancer -- breast cancer -- colorectal cancer -- lupus -- IL-6; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.MR1118-440R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: This review discusses how the measurement of proteins in blood and its components via quantitative proteomics analyses can inform health status. Various external and internal factors such as environmental conditions, genetic background, nutrition, diet, and lifestyle, chronic pathological conditions, disease state, or therapeutic intervention will be investigated and their effects on the protein profile will be shown. The resulting changes to ones' health and how this protein expression information can be used in early screening/diagnostic applications, drug discovery, precision treatment, patient management, and monitoring overall health status will also be presented. Graphical Abstract: Review of how proteomics approaches may be applied to discern unique protein biomarker profiles to aid in diagnosis, treatment, and health monitoring.