Complement modulation of T cell immune responses during homeostasis and disease. Issue 5 (10th September 2014)

• Record Type: Journal Article
• Authors: Clarke, Elizabeth V; Tenner, Andrea J
• Is Part Of: Journal of leukocyte biology. Volume 96:Issue 5(2014)
• Page Start: 745
• Page End: 756
• Publication Date: 2014-09-10
• Subjects: C1q -- C5a -- C3 -- DAF -- CD46; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.3MR0214-109R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on the influence of complement proteins, activation fragments, and regulatory receptors on T cell function, noting differences between humans and mice. ABSTRACT: The complement system is an ancient and critical effector mechanism of the innate immune system as it senses, kills, and clears infectious and/or dangerous particles and alerts the immune system to the presence of the infection and/or danger. Interestingly, an increasing number of reports have demonstrated a clear role for complement in the adaptive immune system as well. Of note, a number of recent studies have identified previously unknown roles for complement proteins, receptors, and regulators in T cell function. Here, we will review recent data demonstrating the influence of complement proteins C1q, C3b/iC3b, C3a (and C3aR), and C5a (and C5aR) and complement regulators DAF (CD55) and CD46 (MCP) on T cell function during homeostasis and disease. Although new concepts are beginning to emerge in the field of complement regulation of T cell function, future experiments should focus on whether complement is interacting directly with the T cell or is having an indirect effect on T cell function via APCs, the cytokine milieu, or downstream complement activation products. Importantly, the identification of the pivotal molecular pathways in the human systems will be beneficial in the translation of concepts derived from model systems to therapeutic targeting for treatment of human disorders.