A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis. (14th February 2023)

• Record Type: Journal Article
• Authors: Rammaert, Blandine; Bochud, Pierre-Yves; Brunel, Anne-Sophie; Wojtowicz, Agnieszka; Candon, Sophie; Gallego Hernanz, Maria Pilar; Lortholary, Olivier
• Is Part Of: Open forum infectious diseases. Volume 10:Number 3(2023)
• Publication Date: 2023-02-14
• Subjects: IL-1B -- Candida spp -- cytokines -- genetic polymorphism -- immune inflammatory reconstitution syndrome -- invasive fungal diseases; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofad078
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.