MTOR and metabolic regulation of conventional and regulatory T cells. Issue 5 (24th February 2015)

• Record Type: Journal Article
• Authors: Liu, Chaohong; Chapman, Nicole M; Karmaus, Peer W F; Zeng, Hu; Chi, Hongbo
• Is Part Of: Journal of leukocyte biology. Volume 97:Issue 5(2015)
• Page Start: 837
• Page End: 847
• Publication Date: 2015-02-24
• Subjects: metabolism -- Tregs -- T cell differentiation -- lipid -- glycolysis; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.2RI0814-408R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review of regulation of mTOR signaling in T cells, and roles of mTOR and metabolic pathways in conventional and regulatory T cells. Abstract: mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs . In this review, we discuss the regulation of mTOR signaling in T cells and the functional impacts of mTOR and metabolic pathways on T cell-mediated immune responses, with a particular focus on the differentiation and function of Tregs .