Cellular and molecular mechanisms involved in the resolution of innate leukocyte inflammation. Issue 3 (24th April 2018)

• Record Type: Journal Article
• Authors: Rahtes, Allison; Geng, Shuo; Lee, Christina; Li, Liwu
• Is Part Of: Journal of leukocyte biology. Volume 104:Issue 3(2018)
• Page Start: 535
• Page End: 541
• Publication Date: 2018-04-24
• Subjects: cellular and molecular mechanisms -- dynamic modulation -- leukocyte homeostasis -- negative regulators -- lysosome fusion; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.3MA0218-070R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Inflammation is a host response to infection or damage and is vital for clearing pathogens and host debris. When this resolution fails to occur, chronic inflammation ensues. Chronic inflammation is typically characterized as a low-grade, persistent inflammatory process that can last for months or even years. This differs from acute inflammation, which is typically a fast, robust response to a stimulus followed by resolution with return to homeostasis. Inflammation resolution occurs through a variety of cellular processes and signaling components that act as "brakes" to keep inflammation in check. In cases of chronic inflammation, these "brakes" are often dysfunctional. Due to its prevalent association with chronic diseases, there is growing interest in characterizing these negative regulators and their cellular effects in innate leukocytes. In this review, we aim to describe key cellular and molecular homeostatic regulators of innate leukocytes, with particular attention to the emerging regulatory processes of autophagy and lysosomal fusion during inflammation resolution. Review on homeostatic processes of innate leukocytes, with particular attention to the emerging roles of autophagy and lysosomal fusion during inflammation resolution.