Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study. Issue 1161 (6th September 2021)

• Record Type: Journal Article
• Authors: Zafar, Mansoor; Karkhanis, Mangala; Shahbaz, Muhammad; Khanna, Alisha; Barry, Lucinda; Alam, Saba; Lawrence, Kamal; Pun, Bipin; Eldebri, Reem; Makanjuola, Opeyemi; Safarova, Dana; Farooq, Mariya; Nooredinavand, Hesam; Cuison, Frderic; Subba, Karuna; Singh Randhawa, Ratan; Hegner, Johannes; Oluwamayowa, Ojofeitimi; Elyasaky, Amr; Adekunle, Bolurin; Periasamy, Manivannan; Abdelbagi, Mohamed; Maryam, Zahra; Khuu, Bao; Esteves Morete, Andreia; Ciroi, Giulio; Moran, Steve; O'Neill, William; Zafar, Maaryah J; Zafar, Nadiyah; Patel, Mirej; Golez, Raphael; Hadid, Abubakr; Muhammad, Tila; Mayhead, Philip; Whitehead, Mark; Dashora, Umesh;
• Is Part Of: Postgraduate medical journal. Volume 98:Issue 1161(2022)
• Page Start: 523
• Page End: 528
• Publication Date: 2021-09-06
• Subjects: COVID-19 -- accident & emergency medicine -- porphyria -- haematology -- internal medicine; Medicine -- Periodicals; 610
• DOI: 10.1136/postgradmedj-2021-140564
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract: Background: The role of vitamin D in increased mortality with SARS-COV-2 virus, namely, COVID-19, remains uncertain. We analysed all the patients who were treated as COVID-19-positive with or without a positive swab and were tested for vitamin D levels. Methods: This was a retrospective, study involving 1226 patients swabbed for SARS-CoV-2 between the 10 February 2020 and 1 May 2020 at two hospitals of East Sussex Healthcare NHS Trust. Patients who were swab-positive for COVID-19 or treated as COVID-19-positive on clinical grounds even though swab results were negative were included in this study. We analysed the association of vitamin D levels and mortality, assessing linear and non-linear associations. Results: A total of 1226 patients had SARS-CoV-2 RNA swabs in this period with age range from 1 year to 101 years. A cohort of 433 of these patients had swabs and recent vitamin D levels anytime in the previous 3 months. Mortality rates were not found to be associated with vitamin D levels (OR=1.04, 95% CI 0.96 to 1.12). Conclusion: Our findings suggest similar mortality risk from COVID-19 irrespective of the levels of vitamin D. Larger prospective studies will be needed to confirm these findings.