Keratinocyte: A trigger or an executor of psoriasis?. Issue 2 (14th March 2020)

• Record Type: Journal Article
• Authors: Ni, Xinhui; Lai, Yuping
• Is Part Of: Journal of leukocyte biology. Volume 108:Issue 2(2020)
• Page Start: 485
• Page End: 491
• Publication Date: 2020-03-14
• Subjects: inflammatory response -- cytokines/chemokines -- onset -- mantainence -- relapse; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.5MR0120-439R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Psoriasis is a common chronic inflammatory skin disease characterized by abnormal proliferation/differentiation of keratinocytes and excessive immune cell infiltration in the dermis and epidermis. Over the past 2 decades, immune cells have been considered as the main driver of psoriasis because the neutralizing antibodies targeting the IL‐23/IL‐17 axis that regulates cross‐talk between dendritic cells and T cells achieve tremendous success in the treatment of psoriasis. However, whether keratinocyte would be a driver of psoriasis or just an executor in response to immune cells is still under debate. In this review, we focus on the recent advances in the identification of keratinocyte as a trigger of psoriasis, summarize on the role of keratinocytes in self‐perpetuating loop to maintain inflammation in psoriasis, and then discuss the possible roles of keratinocytes in the relapse of psoriasis. Graphical Abstract: Review addresses recent advances on keratinocytes in initiation, maintenance, and relapse of psoriasis.