A review of the mechanisms of keratinocytes damage caused by Staphylococcus aureus infection in patients with atopic dermatitis. Issue 6 (29th September 2021)

• Record Type: Journal Article
• Authors: Tian, Xin; Huang, Qiongxiao; Liang, Jingyao; Wang, Jianqin; Zhang, Jing; Yang, Yan; Ye, Qianru; He, Suling; Li, Junlong; Wu, Zhouwei; Liu, Yumei
• Is Part Of: Journal of leukocyte biology. Volume 110:Issue 6(2021)
• Page Start: 1163
• Page End: 1169
• Publication Date: 2021-09-29
• Subjects: adaptive immunity -- atopic dermatitis -- innate immunity -- keratinocytes -- skin barrier -- Staphylococcus aureus; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.3MR0921-030RRR
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: The dysregulation of skin microflora in patients with atopic dermatitis (AD) has become a research hotspot in recent years. Metagenomic studies have shown that microbial diversity is decreased, whereas the Staphylococcus aureus infection is increased in AD. Keratinocytes are the primary barrier against the invasion of external pathogenic microorganisms. Staphylococcus aureus infection can abnormally activate innate and adaptive immune responses in keratinocytes, resulting in a vicious cycle between Staphylococcus aureus infection and AD. This article reviews the mechanisms of inflammatory damage of keratinocytes induced by Staphylococcus aureus infection in patients with AD, providing a theoretical basis for the study of new targeted drugs. This review also suggests for the management of Staphylococcus aureus infection in patients with AD. Graphical Abstract: Review of the mechanisms underlying the immune and inflammatory damage from keratinocytes caused by S. aureus; may help guide treatment options for patients with atopic dermatitis.