Role of gamma-delta (γδ) T cells in autoimmunity. Issue 2 (10th December 2014)

• Record Type: Journal Article
• Authors: Paul, Sourav; , Shilpi; Lal, Girdhari
• Is Part Of: Journal of leukocyte biology. Volume 97:Issue 2(2015)
• Page Start: 259
• Page End: 271
• Publication Date: 2014-12-10
• Subjects: Th17 -- intraepithelial lymphocyte -- inflammation -- multiple sclerosis; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1189/jlb.3RU0914-443R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract : Review on cellular and molecular cross-talk between γδ T cells and adaptive immune cells in the pathogenesis of autoimmune diseases. Abstract: γδ T cells represent a small population of overall T lymphocytes (0.5–5%) and have variable tissue distribution in the body. γδ T cells can perform complex functions, such as immune surveillance, immunoregulation, and effector function, without undergoing clonal expansion. Heterogeneous distribution and anatomic localization of γδ T cells in the normal and inflamed tissues play an important role in alloimmunity, autoimmunity, or immunity. The cross-talk between γδ T cells and other immune cells and phenotypic and functional plasticity of γδ T cells have been given recent attention in the field of immunology. In this review, we discussed the cellular and molecular interaction of γδ T cells with other immune cells and its mechanism in the pathogenesis of various autoimmune diseases.