Organ procurement requiring the authorization of the judicial authority. An epidemiological investigation in the Veneto region (Italy). (March 2023)

• Record Type: Journal Article
• Authors: Cecchetto, Giovanni; De Leo, Domenico; Pancheri, Anna; Franchetti, Giorgia; Proto, Sara; Cocchio, Silvia; Furlan, Patrizia; Corlianò, Pantaleo; Baldo, Vincenzo; Viel, Guido; Feltrin, Giuseppe
• Is Part Of: Legal medicine. Volume 61(2023)
• Publication Date: 2023-03
• Subjects: Organ harvesting -- Organ donors -- Forensic autopsy -- Judicial Authority; Medical jurisprudence -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Medical jurisprudence; Periodicals; 614.1
• DOI: 10.1016/j.legalmed.2023.102218
• Languages: English
• ISSNs: 1344-6223

Abstract

Highlights: The denial of consent by the Judicial Authority causes a loss of organs for transplantation. The limited duration of the death ascertainment procedure represents an obstacle for the procurement process. It is essential to uniform protocols and guidelines and share them with the parties involved. An efficient collaboration between the organizations which manage transplantations and the Judicial Authority is crucial. Abstract: Background: When death occurs through a mechanism requiring a forensic investigation, consent for organ harvesting must be sought from the Judicial Authority (JA). Aim: To perform a retrospective study of potential organ donors in the Veneto region over a six-year period (2012–2017), analysing any differences between cases in which the JA approved or denied organ harvesting. Material and methods: Both non-heart beating (NHB) and heart beating (HB) donors were included. For HB cases, personal and clinical data were collected. To evaluate the correlation between the JA response and the circumstantial and clinical data a logistic multivariate analysis was performed, estimating the adjusted odds ratios (adjORs). Results: Between 2012 and 2017, 17, 662 organ and/or tissue donors were included, of which 16, 418 were NHB donors and 1, 244 HB-donors. Among the 1, 244 HB-donors, JA authorization was asked in 200 cases (16.1%), approved in 154 cases (77.0%), limited in 7 cases (3.5%) and denied in 39 cases (19.5%). The JA denied the authorization for organ harvesting in 53, 3% of cases with hospitalizations of less than 1 day and in 9, 4% of cases with hospitalization exceeding one week [adjOR(95%CI) = 10.67 (1.92–59.22)]. The performance of an autopsy was linked to a higher chance of denied outcome from the JA [adjOR(95%CI): 3.45 (1.42–8.39)]. Conclusions: Improvements in the communication between organ procurement organizations and the JA through efficient protocols furnishing detailed information on the cause of death might lead to a better procurement process with an increase in the number of transplanted organs.