SARS-CoV-2 viral shedding in vaccinated and unvaccinated persons: A case series. Issue 11 (10th March 2023)

• Record Type: Journal Article
• Authors: McCormick, David W.; Hagan, Liesl M.; Salvatore, Phillip P.; Magleby, Reed; Lee, Christine; Sleweon, Sadia; Nicolae, Lavinia; Dixon, Tom; Banta, Robert; Ogle, Isaac; Young, Cristen; Dusseau, Charles; Ogden, Charles; Browne, Hannah; Michael Metz, John; Chen, Min-hsin; Solano, Maria I.; Rogers, Shannon; Burgin, Alex; Sheth, Mili; Bankamp, Bettina; Tamin, Azaibi; Harcourt, Jennifer L.; Tate, Jacqueline E.; Kirking, Hannah L.
• Is Part Of: Vaccine. Volume 41:Issue 11(2023)
• Page Start: 1769
• Page End: 1773
• Publication Date: 2023-03-10
• Subjects: SARS-CoV-2 -- COVID-19 vaccines -- Prisons -- Virus shedding; BMI body mass index -- BOP Bureau of Prisons -- CDC US Centers for Disease Control and Prevention -- Ct cycle threshold -- RT-PCR reverse transcription polymerase chain reaction; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2022.11.030
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: The preclinical time course of SARS-CoV-2 shedding is not well-described. Understanding this time course will help to inform risk of SARS-CoV-2 transmission. During an outbreak in a congregate setting, we collected paired mid-turbinate nasal swabs for antigen testing and reverse-transcription polymerase chain reaction (RT-PCR) every other day from all consenting infected and exposed persons. Among 12 persons tested prospectively before and during SARS-CoV-2 infection, ten of 12 participants (83%) had completed a primary COVID-19 vaccination series prior to the outbreak. We recovered SARS-CoV-2 in viral culture from 9/12 (75%) of participants. All three persons from whom we did not recover SARS-CoV-2 in viral culture had completed their primary vaccination series. We recovered SARS-CoV-2 from viral culture in 6/9 vaccinated persons and before symptom onset in 3/6 symptomatic persons. These findings underscore the need for both non-pharmaceutical interventions and vaccination to mitigate transmission.