Emerging markers of inflammation and oxidative stress as potential predictors of coronary artery disease. (1st April 2023)

• Record Type: Journal Article
• Authors: Tsirebolos, George; Tsoporis, James N.; Drosatos, Ioannis-Alexandros; Izhar, Shehla; Gkavogiannakis, Nikolaos; Sakadakis, Eleftherios; Triantafyllis, Andreas S.; Parker, Thomas G.; Rallidis, Loukianos S.; Rizos, Ioannis
• Is Part Of: International journal of cardiology. Volume 376(2023)
• Page Start: 127
• Page End: 133
• Publication Date: 2023-04-01
• Subjects: Coronary artery disease -- Diabetes -- AGE/sRAGE -- DJ-1 -- Inflammation -- Oxidative stress; RAGE Receptor for advanced glycation end products -- AGE Advanced glycation end products -- CAD Coronary artery disease -- sRAGE Soluable RAGE -- CV Cardiovascular -- BMI Body mass index -- GFR Glomerular filtration rate -- LVEF Left ventricular ejection fraction -- HDL-C High density lipoprotean C -- LDL-C Low density lipoprotean C -- IQR Interquartile range -- VD Vascular disease -- DM Diabetes mellitus -- CRP C reactive protein -- IL-6 Interleukin - 6 -- ACS Acute coronary syndrome; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2023.02.005
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background and aims: The multi-ligand receptor for advanced glycation end products (RAGE) and its ligands AGEs and S100/calgranulin proteins are important mediators of inflammation and oxidative stress whereas the soluble form of RAGE (sRAGE) by acting as a decoy and the antioxidant PARK7/DJ-1 exert antiatherogenic effects. We examined whether sRAGE and its ligands AGEs, S100A8/A9, S100B, S100A12 and DJ-1 are associated with the presence of angiographic coronary artery disease (CAD) in asymptomatic patients with and without diabetes. Methods and results: Plasma levels of RAGE ligands, sRAGE and DJ-1 were determined in 50 patients with angiographically proven CAD and in 50 age-matched healthy controls. In the whole cohort, lower levels of sRAGE and higher levels of interleukin-6 (IL-6), the RAGE ligands S100B, S100A12 and the AGEs/sRAGE ratio were associated with CAD. In patients without diabetes ( n = 72), lower levels of sRAGE and DJ-1 and higher levels of IL-6 and AGEs/sRAGE ratio were associated with CAD. In multivariable analysis, AGEs/sRAGE ratio was an independent predictor of CAD both in the whole cohort ( p = 0.034, OR = 1.247, [95%CI: 1.024, 1.0519]) and in the subgroup of patients without diabetes ( p = 0.021, OR = 1.363, 95%CI [1.048, 1.771]) on top of established cardiovascular risk factors. Conclusion: Alterations in plasma RAGE axis inflammatory mediators are associated with atherosclerosis, and higher levels of AGEs/sRAGE ratio are independently associated with CAD in asymptomatic patients and may act as a novel biomarker for predicting CAD. DJ-1 emerges as promising marker of oxidative stress in CAD patients without diabetes, a finding that deserves further study. Highlights: In the cohort, CAD patients had higher IL-6, S100B, S100A12 and AGEs/sRAGE ratio and lower of sRAGE compared with controls. CAD patients without diabetes had higher IL-6, AGEs/sRAGE ratio and lower sRAGE and DJ-1 compared with controls. The soluble form of RAGE (sRAGE) by acting as a decoy and the antioxidant PARK7/DJ-1 may exert antiatherogenic effects. AGEs/sRAGE ratio is independently associated with CAD, on top of established cardiovascular risk factors.