Secondary metabolites from marine derived fungus Penicillium chrysogenum Y19-1 with proangiogenic and antithrombotic activities. (April 2023)

• Record Type: Journal Article
• Authors: Li, Peihai; Xie, Dongxiao; Chen, Hao; Qiu, Yuezi; Zhang, Xuanming; Zhang, Shanshan; Wang, Lizhen; Lin, Houwen; Li, Xiaobin; Liu, Kechun
• Is Part Of: Biochemical systematics and ecology. Volume 107(2023)
• Publication Date: 2023-04
• Subjects: Marine derived fungus -- Penicillium chrysogenum -- Chemotaxonomy -- Proangiogenic and antithrombotic activity; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2023.104625
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: Investigation of the ethyl acetate extract from the marine derived fungus Penicillium chrysogenum Y19-1 led to the isolation and identification of nine compounds, including ethyl formyltyrosinate (1 ), ergosterol peroxide (2 ), ergosterol (3 ), cerebroside A (4 ), conidiogenone C (5 ), dihydroresorcylide (6 ), 7-hydroxydihydroresorcylide (7 ), N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide (8 ), and 4-methyl-5, 6-dihydro-2H-pyran-2-one (9 ). Their chemical structures were determined by NMR analysis, ESIMS experiment and comparison with the reported data in the literature. Among them, compound 1 was identified as a natural product for the first time. All compounds were evaluated for antithrombotic and proangiogenic activities. Compounds 1, 4 and 5 exhibited antithrombotic activities, while compounds 1, 2, 8 and 9 showed proangiogenic activities. Meanwhile, the chemotaxonomic significance of these isolated compounds was also discussed. Highlights: Nine compounds were isolated from Penicillium chrysogenum Y19-1. Ethyl formyltyrosinate was identified as a natural product for the first time. All compounds were evaluated for antithrombotic and proangiogenic activities. Chemotaxonomic significance of these compounds was described.