Hyperbaric Oxygen Therapy Combined with Immunosuppression for Acute Macular Neuroretinopathy in Systemic Lupus Erythematosus. (7th February 2023)

• Record Type: Journal Article
• Authors: Shroff, Daraius; Kothari, Abhishek; Gupta, Priyanka; Sahni, Tarun Kumar; Narain, Shishir
• Is Part Of: Ocular immunology and inflammation. Volume 31:Number 2(2023)
• Page Start: 355
• Page End: 361
• Publication Date: 2023-02-07
• Subjects: Acute macular neuroretinopathy -- Hyperbaric oxygen therapy -- Immunosuppression -- Optical coherence tomography -- Systemic lupus erythematosus -- Visual fields; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2022.2029497
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To describe the use of hyperbaric oxygen therapy (HBOT) in conjunction with immunosuppression for acute macular neuroretinopathy (AMN) in systemic lupus erythematosus (SLE). Methods: Two known cases of SLE presented to us with blurred vision and paracentral scotomas due to AMN. Both cases reported worsening of their conditions despite the initiation of high-dose steroid therapy. HBOT was added on as a treatment modality to address vaso-occlusive ischemic injury. Results: Both patients underwent a total of twelve cycles of HBOT. Functional and anatomical improvements were noted immediately after the initiation of therapy and were maintained over more than one year of follow-up. No significant retinal thinning was noted on optical coherence tomography on disease resolution, as has been noted previously. Visual field scotoma showed a complete resolution. Conclusion: Our cases suggest that HBOT may have a role in aiding functional and anatomical recovery in AMN associated with SLE.