Isocyanide chemistry enabled by continuous flow technology. Issue 3 (9th December 2022)

• Record Type: Journal Article
• Authors: Cerra, Bruno; Blondeau, Cecile; Cannalire, Rolando; Giustiniano, Mariateresa; Tali Shandiz, Shiva; Gioiello, Antimo
• Is Part Of: Reaction chemistry & engineering. Volume 8:Issue 3(2023)
• Page Start: 656
• Page End: 660
• Publication Date: 2022-12-09
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/d2re00454b
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : The potential of continuous flow technology to streamline the synthesis, purification and postmodification reactions of isocyanides is reported. Abstract : Isocyanides are valuable compounds for organic synthesis. However, the poor stability and distressing odour have often limited their widespread applications in common laboratory practice and industrial settings. Herein, a continuous flow approach to enable the synthesis, purification and in-line reaction of isocyanides is presented.