Inflammatory mediators in nasal secretions of patients with nasal polyposis with and without aspirin sensitivity. Issue 2 (23rd February 2023)

• Record Type: Journal Article
• Authors: Perić, Aleksandar; Gaćeša, Dejan; Cvetković, Gordana; Vojvodić, Danilo
• Is Part Of: Immunity, inflammation and disease. Volume 11:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-23
• Subjects: aspirin -- eosinophils -- mast cells -- nasal polyps -- respiratory mucosa; Immunology -- Periodicals; Immunity -- Periodicals; Inflammation -- Periodicals; 616.079
• DOI: 10.1002/iid3.791
• Languages: English
• ISSNs: 2050-4527

Abstract

Abstract: Background: The aim of this cross‐sectional study was to compare the levels of inflammatory mediators in nasal secretions in patients with aspirin‐exacerbated respiratory disease (AERD) and in those with nasal polyposis (NP) without aspirin‐sensitivity and to correlate nasal fluid mediator concentrations with clinical parameters of the disease. Methods: A total of 30 patients with AERD, 30 chronic rhinosinusitis (CRS) with NP patients without aspirin sensitivity (CRSwNP), and 30 control subjects without inflammation of the nasal mucosa (C), selected for surgical treatment entered the study. The total nasal symptom score (TNSS), endoscopic score (ES), and Lund‐Mackay score (LMS), were evaluated. The concentrations of eosinophil cationic protein (ECP), tryptase, heat shock protein 70 (HSP70), substance P and Clara cell protein 16 (CC16) were determined in nasal secretions. Results: Higher concentrations of ECP, tryptase, and HSP70 were measured in the AERD patients than in the CRSwNP patients and the C group ( p < .001; p < .001, respectively for all mediators). However, levels of CC16 were higher in the C group than in the AERD and CRSwNP groups ( p < .001; p < .001, respectively). A positive correlation between the TNSS and CC16 and a negative one between CC16 and tryptase levels were found in the C group. The CRSwNP group showed positive correlations between ECP, HSP70, and tryptase and negative correlations between substance P, ES, and LMS, as well as between CC16 and tryptase levels. In the AERD group, we found a positive correlation between HSP70 and ECP levels and a negative correlation between the TNSS and CC16 concentration. Conclusion: The obtained results indicate the increased production of mediators of eosinophil and mast cell function, and the decreased production of biomarker of respiratory epithelial function in AERD patients. Clinical and biochemical parameters correlate in different ways in the AERD and CRSwNP patients. Abstract : Our results showed higher concentrations of ECP, HSP70 and tryptase in AERD patients than in nonaspirin sensitized CRSwNP patients and in subjects with healthy nasal mucosa. Clinical and biochemical parameters of chronic inflammation correlate in different ways in AERD and nonaspirin sensitized CRSwNP patients, suggesting the posibility that different inflammatory mechanisms are involved in the development of these two forms of disease.