Neural crest cells development and neuroblastoma progression: Role of Wnt signaling. Issue 2 (11th December 2022)

• Record Type: Journal Article
• Authors: Ahmad, Mir Hilal; Ghosh, Balaram; Rizvi, Moshahid Alam; Ali, Mansoor; Kaur, Loveleena; Mondal, Amal Chandra
• Is Part Of: Journal of cellular physiology. Volume 238:Issue 2(2023)
• Page Start: 306
• Page End: 328
• Publication Date: 2022-12-11
• Subjects: cancer -- embryogenesis -- neural crest -- neuroblastoma -- Wnt/β‐catenin; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30931
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Neuroblastoma (NB) is one of the most common heterogeneous extracranial cancers in infancy that arises from neural crest (NC) cells of the sympathetic nervous system. The Wnt signaling pathway, both canonical and noncanonical pathway, is a highly conserved signaling pathway that regulates the development and differentiation of the NC cells during embryogenesis. Reports suggest that aberrant activation of Wnt ligands/receptors in Wnt signaling pathways promote progression and relapse of NB. Wnt signaling pathways regulate NC induction and migration in a similar manner; it regulates proliferation and metastasis of NB. Inhibiting the Wnt signaling pathway or its ligands/receptors induces apoptosis and abrogates proliferation and tumorigenicity in all major types of NB cells. Here, we comprehensively discuss the Wnt signaling pathway and its mechanisms in regulating the development of NC and NB pathogenesis. This review highlights the implications of aberrant Wnt signaling in the context of etiology, progression, and relapse of NB. We have also described emerging strategies for Wnt‐based therapies against the progression of NB that will provide new insights into the development of Wnt‐based therapeutic strategies for NB. Abstract : Wnt signaling pathway regulates both the development of neural crest and progression of Neuroblastoma