Two‐Dimensional FePS3 Nanosheets as an Integrative Sonosensitizer/Nanocatalyst for Efficient Nanodynamic Tumor Therapy. Issue 8 (23rd December 2022)

• Record Type: Journal Article
• Authors: Lin, Shiyang; Yang, Mai; Chen, Jiajie; Feng, Wei; Chen, Yu; Zhu, Yufang
• Is Part Of: Small. Volume 19:Issue 8(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-23
• Subjects: chemodynamic therapy -- FePS 3 nanosheets -- metal phosphorus trichalcogenides -- semiconductor sonosensitizers -- sonodynamic therapy; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202204992
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: As the emerging modalities for tumor therapy, sonodynamic therapy (SDT) and chemodynamic therapy (CDT) can generate reactive oxygen species (ROS), typically inducing tumor cell apoptosis. However, the construction of more efficient sonosensitizers integrated with excellent Fenton/Fenton‐like catalytic activity to improve the synergistic therapeutic effect of SDT and CDT is still highly challenging. In this study, 2D semiconductor FePS3 nanosheets (NSs), as one of the metal phosphorus trichalcogenides for both sonosensitizer and Fenton catalyst, are successfully synthesized via an ultrasonic‐assisted liquid phase exfoliation method from bulk FePS3 and further modified with lipoic acid‐polyethylene glycol (LA‐PEG) to obtain FePS3 ‐PEG NSs with desirable biocompatibility. The in vitro and in vivo results demonstrate that the engineered FePS3 ‐PEG NSs induce the combinatorial SDT/CDT effect attributing to the enhanced ROS generation and significant glutathione depletion, which can conduct highly efficient and safe tumor inhibition and prolong the life span of tumor‐bearing mice. This work provides the paradigm of semiconductor FePS3 NSs as the integrative sonosensitizer/Fenton nanocatalyst for dual nanodynamic tumor therapy, paving the new way for exploring other 2D metal phosphorus trichalcogenides in biomedicine. Abstract : Two‐dimensional semiconductor FePS3 nanosheets (NSs), as an efficient integrative sonosensitizer/Fenton catalyst, are successfully synthesized and modified with lipoic acid‐polyethylene glycol (FePS3 ‐PEG NSs), which could generate ROS (OH and 1 O2 ) to achieve efficient combined sonodynamic/chemodynamic therapy of tumors. Furthermore, glutathione depletion could amplify the ROS‐induced oxidative stress, thereby further enhancing the tumor therapeutic effect.