The effects of time‐restricted eating and weight loss on bone metabolism and health: a 6‐month randomized controlled trial. (14th October 2022)

• Record Type: Journal Article
• Authors: Papageorgiou, Maria; Biver, Emmanuel; Mareschal, Julie; Phillips, Nicholas Edward; Hemmer, Alexandra; Biolley, Emma; Schwab, Nathalie; Manoogian, Emily N. C.; Gonzalez Rodriguez, Elena; Aeberli, Daniel; Hans, Didier; Pot, Caroline; Panda, Satchidananda; Rodondi, Nicolas; Ferrari, Serge L.; Collet, Tinh‐Hai
• Other Names: Manoogian Emily N. C. guestEditor.; Laferrère Blandine guestEditor.; Heilbronn Leonie guestEditor.
• Is Part Of: Obesity. Volume 31(2023)Supplement 1
• Page Start: 85
• Page End: 95
• Publication Date: 2022-10-14
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.23577
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract: Objective: This study explored the impact of time‐restricted eating (TRE) versus standard dietary advice (SDA) on bone health. Methods: Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x‐ray absorptiometry were assessed at baseline and 6‐month follow‐up. Statistical analyses were performed in the total population and by weight loss response. Results: In the total population ( n = 42, 76% women, median age 47 years [IQR: 31‐52]), there were no between‐group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β‐carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between‐group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N‐propeptide did not differ between groups. Total body bone mineral content decreased after SDA ( p = 0.028) but remained unchanged after TRE ( p = 0.31) in weight loss responders (between‐group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between‐group differences in bone outcomes. Conclusions: TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone‐sparing effects compared with SDA.