Eight‐hour time‐restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial. (22nd December 2022)

• Record Type: Journal Article
• Authors: Parr, Evelyn B.; Kouw, Imre W. K.; Wheeler, Michael J.; Radford, Bridget E.; Hall, Rebecca C.; Senden, Joan M.; Goessens, Joy P. B.; van Loon, Luc J. C.; Hawley, John A.
• Other Names: Manoogian Emily N. C. guestEditor.; Laferrère Blandine guestEditor.; Heilbronn Leonie guestEditor.
• Is Part Of: Obesity. Volume 31(2023)Supplement 1
• Page Start: 116
• Page End: 126
• Publication Date: 2022-12-22
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.23637
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract: Objective: This study aimed to assess the impact of time‐restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity. Methods: A total of 18 healthy males (age 46 ± 5 years; BMI: 30 ± 2 kg/m 2 ) completed this exploratory, parallel, randomized dietary intervention after a 3‐day lead‐in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual‐energy x‐ray absorptiometry). Results: There were no differences in daily integrated MyoPS rates (TRE: 1.28% ± 0.18% per day, CON: 1.26% ± 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24‐hour total area under the curve was reduced following TRE (−578 ± 271 vs. CON: 12 ± 272 mmol/L × 24 hours; p = 0.001). Total body mass declined (TRE: −1.6 ± 0.9 and CON: −1.1 ± 0.7 kg; p < 0.001) with no differences between groups ( p = 0.22). Lean mass loss was greater following TRE compared with CON (−1.0 ± 0.7 vs. −0.2 ± 0.5 kg, respectively; p = 0.01). Conclusion: Consuming food within an 8‐hour time‐restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free‐living TRE.