Radiation Therapy for Primary Cutaneous Gamma Delta Lymphoma Prior to Stem Cell Transplantation. (16th March 2023)

• Record Type: Journal Article
• Authors: Wu, Yufan F.; Skinner, Lawrie; Lewis, Jonathan; Khodadoust, Michael S.; Kim, Youn H.; Kwong, Bernice Y.; Weng, Wen-Kai; Hoppe, Richard T.; Sodji, Quaovi; Hui, Caressa; Kastelowitz, Noah; Fernandez-Pol, Sebastian; Hiniker, Susan M.
• Is Part Of: Cancer investigation. Volume 41:Number 3(2023)
• Page Start: 263
• Page End: 270
• Publication Date: 2023-03-16
• Subjects: Lymphomas -- radiation oncology -- bone marrow transplant; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2021.1919696
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: We present a patient with widespread PCGD-TCL of the bilateral arms and legs, who underwent radiotherapy with 34 Gy in 17 fractions using circumferential VMAT and 3-D printed bolus to the four extremities prior to planned stem cell transplant, who was then found to have progression in the liver, lung, and skin, followed by drastic regression of all in and out-of-field lesions on imaging 1.5 months later. The cause of regression may be related to a radiation-induced abscopal effect from the immunomodulatory effects of radiation, or related to immune reactivation in the setting of cessation of systemic immunosuppressive agents.