Current opinions on mitophagy in fungi. Issue 3 (4th March 2023)
- Record Type:
- Journal Article
- Title:
- Current opinions on mitophagy in fungi. Issue 3 (4th March 2023)
- Main Title:
- Current opinions on mitophagy in fungi
- Authors:
- Shen, Zi-Fang
Li, Lin
Zhu, Xue-Ming
Liu, Xiao-Hong
Klionsky, Daniel J.
Lin, Fu-Cheng - Abstract:
- ABSTRACT: Mitophagy, as one of the most important cellular processes to ensure quality control of mitochondria, aims at transporting damaged, aging, dysfunctional or excess mitochondria to vacuoles (plants and fungi) or lysosomes (mammals) for degradation and recycling. The normal functioning of mitophagy is critical for cellular homeostasis from yeasts to humans. Although the role of mitophagy has been well studied in mammalian cells and in certain model organisms, especially the budding yeast Saccharomyces cerevisiae, our understanding of its significance in other fungi, particularly in pathogenic filamentous fungi, is still at the preliminary stage. Recent studies have shown that mitophagy plays a vital role in spore production, vegetative growth and virulence of pathogenic fungi, which are very different from its roles in mammal and yeast. In this review, we summarize the functions of mitophagy for mitochondrial quality and quantity control, fungal growth and pathogenesis that have been reported in the field of molecular biology over the past two decades. These findings may help researchers and readers to better understand the multiple functions of mitophagy and provide new perspectives for the study of mitophagy in fungal pathogenesis. Abbreviations: AIM/LIR: Atg8-family interacting motif/LC3-interacting region; BAR: Bin–Amphiphysin–Rvs; BNIP3: BCL2 interacting protein 3; CK2: casein kinase 2; Cvt: cytoplasm-to-vacuole targeting; ER: endoplasmic reticulum; IMM: innerABSTRACT: Mitophagy, as one of the most important cellular processes to ensure quality control of mitochondria, aims at transporting damaged, aging, dysfunctional or excess mitochondria to vacuoles (plants and fungi) or lysosomes (mammals) for degradation and recycling. The normal functioning of mitophagy is critical for cellular homeostasis from yeasts to humans. Although the role of mitophagy has been well studied in mammalian cells and in certain model organisms, especially the budding yeast Saccharomyces cerevisiae, our understanding of its significance in other fungi, particularly in pathogenic filamentous fungi, is still at the preliminary stage. Recent studies have shown that mitophagy plays a vital role in spore production, vegetative growth and virulence of pathogenic fungi, which are very different from its roles in mammal and yeast. In this review, we summarize the functions of mitophagy for mitochondrial quality and quantity control, fungal growth and pathogenesis that have been reported in the field of molecular biology over the past two decades. These findings may help researchers and readers to better understand the multiple functions of mitophagy and provide new perspectives for the study of mitophagy in fungal pathogenesis. Abbreviations: AIM/LIR: Atg8-family interacting motif/LC3-interacting region; BAR: Bin–Amphiphysin–Rvs; BNIP3: BCL2 interacting protein 3; CK2: casein kinase 2; Cvt: cytoplasm-to-vacuole targeting; ER: endoplasmic reticulum; IMM: inner mitochondrial membrane; mETC: mitochondrial electron transport chain; OMM: outer mitochondrial membrane; OPTN: optineurin; PAS: phagophore assembly site; PD: Parkinson disease; PE: phosphatidylethanolamine; PHB2: prohibitin 2; PX: Phox homology; ROS, reactive oxygen species; TM: transmembrane. … (more)
- Is Part Of:
- Autophagy. Volume 19:Issue 3(2023)
- Journal:
- Autophagy
- Issue:
- Volume 19:Issue 3(2023)
- Issue Display:
- Volume 19, Issue 3 (2023)
- Year:
- 2023
- Volume:
- 19
- Issue:
- 3
- Issue Sort Value:
- 2023-0019-0003-0000
- Page Start:
- 747
- Page End:
- 757
- Publication Date:
- 2023-03-04
- Subjects:
- Fission -- fungi -- mitochondria -- mitophagy -- pathogenesis -- quantity and quality control
Autophagic vacuoles -- Periodicals
Apoptosis -- Periodicals
Cell death -- Periodicals
Lysosomes -- Periodicals
Degeneration (Pathology) -- Periodicals
Autophagy -- Periodicals
Cell Death -- Periodicals
Lysosomes -- Periodicals
Periodicals
571.936 - Journal URLs:
- http://www.tandfonline.com/loi/kaup20#.Vd3NN_lVhBc ↗
http://www.landesbioscience.com/journals/autophagy ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/15548627.2022.2098452 ↗
- Languages:
- English
- ISSNs:
- 1554-8627
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 1835.065800
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 26065.xml