Cytotoxic ent-abietane diterpenoids from the leaves of Croton lachnocarpus Benth. Issue 4 (3rd April 2023)

• Record Type: Journal Article
• Authors: Wang, Wei; Zhang, Xiao-Jie
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 4(2023)
• Page Start: 309
• Page End: 315
• Publication Date: 2023-04-03
• Subjects: Croton lachnocarpus -- Euphorbiaceae -- ent-abietane diterpenoids -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2090346
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A phytochemical investigation on the 90% ethanol extract of the leaves of Croton lachnocarpus Benth. led to three new ent -abietane diterpenoids, 7 β, 15-dihydroxy- ent -abieta-8, 11, 13-trien-3-one (1 ), 2 β, 15-dihydroxy- ent -abieta-8, 11, 13-triene (2 ), and 7 β, 13 α, 15-trihydroxy- ent -abieta-8(14)-en-3-one (3 ). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D ( 1 H - 1 H COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to electronic circular dichroism (ECD) spectra. The isolated compounds were tested in vitro for cytotoxic activity against 6 tumor cell lines. As a result, compound 3 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 30 μM. Graphical Abstract: UF0001