3, 6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway. Issue 4 (3rd April 2023)

• Record Type: Journal Article
• Authors: Wang, Yun-Ting; Wang, Han; Ren, Wu-Jiang; Dai, Xue-Ling; Huo, Qing; Wang, Shuo; Sun, Ya-Xuan
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 4(2023)
• Page Start: 387
• Page End: 402
• Publication Date: 2023-04-03
• Subjects: Alzheimer's disease -- BDNF -- TrkB -- LPS -- neuroinflammation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2069565
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The aim of this study is to explore the effect and mechanism of 3, 6'-disinapoylsucrose (DISS) on an Alzheimer's disease (AD) mice model induced by APPswe695 lentivirus (LV) and intraperitoneal injection of lipopolysaccharide (LPS). The results show that DISS improves cognitive ability, decreases the levels of IL-2, IL-6, IL-1β, and TNF-α, reduces the expression of NF-κB p65, and alleviates Aβ deposition and nerve cell damage. DISS can regulate tyrosine kinase B (TrkB)/brain-derived neurotrophic factor (BDNF) signaling in the hippocampus. In summary, DISS can significantly alleviate neuroinflammation, spatial learning and memory disorders in AD model mice. Graphical Abstract: UF0001