A mechanically tough and ultra-swellable microneedle for acute gout arthritis. (11th January 2023)

• Record Type: Journal Article
• Authors: Jiang, Suping; Wang, Wen; Ke, Jiming; Huang, Shan; Wang, Jie; Luo, Chengxi; Li, Xiaoxia; Zhang, Kaili; Liu, Huanhuan; Zheng, Wensheng; Zhang, Jiwen; Peng, Can
• Is Part Of: Biomaterials science. Volume 11:Number 5(2023)
• Page Start: 1714
• Page End: 1724
• Publication Date: 2023-01-11
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d2bm01937j
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A tough and ultra-swellable microneedle was fabricated using in situ photopolymerization. Colchicine release was triggered by diffusion when microneedles were used on MSU-induced acute gout rats, resulting in decreased levels of inflammatory cytokines. Abstract : Acute gout arthritis (AGA) remains the fundamental research focus in the entire medical field. Hydrogel microneedles (HMNs) loaded with therapeutic molecules such as colchicine (Col) have been developed as a new tool for the management of AGA in a minimally invasive manner. However, the incompatible mechanical and swelling properties of HMNs limited the diffusion of the drug from the HMN system, which remains a challenge for practical use. Here, a mechanically tough (11.53 N per needle) and super-swelling (2708%) hydrogel microneedle (HMNs) composed of a uniform network structure was developed using a UV-responsive crosslinker through in situ photopolymerization for percutaneous delivery of Col. Such HMNs and Col loaded HMNs (Col-HMNs) present excellent biocompatibility. Moreover, Col-HMNs present considerable anti-inflammatory effects in vivo through down-regulated inflammatory responses such as related cytokines IL-1β, IL-6, and TNF-α. These results demonstrated that the mechanically tough and super-swelling HMNs could be a promising tool for effective Col delivery to relieve AGA.