18F-FMISO PET of an Intracranial Tuberculoma: A Great Mimicker. (27th April 2023)

• Record Type: Journal Article
• Authors: Sakata, Akihiko; Fushimi, Yasutaka; Arakawa, Yoshiki; Shimizu, Yoichi; Nakamoto, Yuji
• Is Part Of: Clinical nuclear medicine. Volume 48:Number 4(2023)
• Page Start: e212
• Page End: e213
• Publication Date: 2023-04-27
• Subjects: tuberculosis -- hypoxia -- 18F-fluoromisonidazole -- 18F-fluorodeoxyglucose -- positron emission tomography; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004471
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: Solitary intracranial tuberculomas are rare and frequently misdiagnosed as brain tumors. We report a case of intracranial tuberculous granuloma mimicking a high-grade glioma with avid uptake on 18 F-fluoromisonidazole PET/CT. It has been believed that hypoxia exists within the tuberculosis granuloma, and that this hypoxic environment causes Mycobacterium tuberculosis to lie dormant and asymptomatic infection to occur. This hypoxic and necrotic condition inside tuberculous granuloma may lead to high accumulation of 18 F-fluoromisonidazole in this case.