A CASE OF HIGH-RISK CILIARY BODY MELANOMA ARISING IN AN EYE AFTER RESECTION OF AN IRIDOCILIARY MELANOCYTOMA. Issue Volume 17:Issues 2(2023) (March 2023)

• Record Type: Journal Article
• Authors: Lee, Terry; Semenova, Ekaterina; Proia, Alan D.; Materin, Miguel A.
• Is Part Of: Retinal cases & brief reports. Volume 17:Issues 2(2023)
• Page Start: 126
• Page End: 129
• Publication Date: 2023-03
• Subjects: brachytherapy -- iridociliary melanocytoma -- iridociliary melanoma -- malignant transformation -- secondary glaucoma; Retina -- Diseases -- Periodicals; Retina -- Periodicals; Retinal Diseases -- Periodicals; Retina -- Case Reports; Retinal Diseases -- Case Reports; 617.7
• DOI: 10.1097/ICB.0000000000001178
• Languages: English
• ISSNs: 1935-1089

Abstract

Abstract : We present a case of a 40-year-old woman with a ciliary body malignant melanoma of high metastatic potential that arose 5 years after excision of a benign iridociliary melanocytoma at the same site. Abstract : Purpose: To report a case of a benign iridociliary melanocytoma recurring as malignant melanoma after excision. Methods: Observational case report with clinical data, slit-lamp examination findings, ultrasound biomicroscopy results, and histopathological and genetic analyses. Results: A 40-year-old African American woman initially presented with a superonasal iridociliary mass with a maximal thickness of 2.5 mm. Visual acuity of the involved eye was 20/25, intraocular pressure was 52 mmHg on maximal pressure-lowering medications, and Humphrey visual field testing revealed an inferior altitudinal defect. Fine-needle aspiration biopsy and incisional biopsy followed by tumor excision confirmed a benign melanocytoma. After 5 years of stability, possible recurrence was detected on ultrasound biomicroscopy as an increase in ciliary body thickness. The new lesion grew to a thickness of 5.1 mm over the next 18 months of observation. Fine-needle aspiration biopsy and gene expression profile of the recurrent lesion diagnosed a malignant melanoma with high metastatic potential (Class 2). The patient underwent plaque brachytherapy and has ongoing regression of the tumor. Conclusion: Transformation of benign iridociliary melanocytoma to melanoma is rare. To the best of the authors' knowledge, this is the first documented case of a melanoma arising in an eye after initial excision of a melanocytoma. Close monitoring of these patients is warranted even years after the initial excision.