Nodular Fasciitis: False Positive on 18F-Piflufolastat and 11C-Choline PET/CT. (12th April 2023)

• Record Type: Journal Article
• Authors: Pitot, Marika A.; Broski, Stephen M.; Thompson, Scott M.; Woodrum, David A.; Powell, Garret M.
• Is Part Of: Clinical nuclear medicine. Volume 48:Number 4(2023)
• Page Start: e209
• Page End: e211
• Publication Date: 2023-04-12
• Subjects: choline -- nodular fasciitis -- piflufolastat -- PSMA; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004538
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: PET/CT plays a crucial role in the management of prostate cancer with several emerging and established radiopharmaceuticals, including 18 F-piflufolastat and 11 C-choline. These radiotracers are thought to be relatively specific to prostate cancer; however, uptake has also been demonstrated in other benign and malignant lesions. Nodular fasciitis is a rapidly growing benign soft tissue neoplasm that is typically self-limiting. Although a few case reports describe 68 Ga-PSMA uptake in nodular fasciitis, uptake of 11 C-choline and other PSMA-targeted PET probes, including 18 F-piflufolastat, have not previously been reported. We present a novel case of nodular fasciitis demonstrating both 18 F-piflufolastat and 11 C-choline avidity.