Clinically Ineffective Reperfusion After Endovascular Therapy in Acute Ischemic Stroke. Issue 3 (7th December 2022)

• Record Type: Journal Article
• Authors: Nie, Ximing; Leng, Xinyi; Miao, Zhongrong; Fisher, Marc; Liu, Liping
• Is Part Of: Stroke. Volume 54:Issue 3(2023)
• Page Start: 873
• Page End: 881
• Publication Date: 2022-12-07
• Subjects: edema -- ischemic stroke -- no -- reflow phenomenon -- reperfusion -- risk factors; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.122.038466
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large vessel occlusion. However, in clinical practice, nearly half of the patients do not have favorable outcomes despite successful recanalization of the occluded artery. This unfavorable outcome can be defined as having clinically ineffective reperfusion. The objective of the review is to describe clinically ineffective reperfusion after endovascular therapy and its underlying risk factors and mechanisms, including initial tissue damage, cerebral edema, the no-reflow phenomenon, reperfusion injury, procedural features, and variations in postprocedural management. Further research is needed to more accurately identify patients at a high risk of clinically ineffective reperfusion after endovascular therapy and to improve individualized periprocedural management strategies, to increase the chance of achieving favorable clinical outcomes.