Altered Biodistribution on 99mTc-Dimercaptosuccinic Acid Renal Scan. (12th April 2023)

• Record Type: Journal Article
• Authors: Mercer, Megan K.; Parisi, Marguerite T.; Revels, Jonathan W.; Blacklock, Lisa; Elojeimy, Saeed
• Is Part Of: Clinical nuclear medicine. Volume 48:Number 4(2023)
• Page Start: e170
• Page End: e172
• Publication Date: 2023-04-12
• Subjects: DMSA -- hepatosplenomegaly -- kidneys -- hematologic disorder; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004528
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: 99m Tc-dimercaptosuccinic acid ( 99m Tc-DMSA) scans are used to evaluate renal cortical defects typically related to parenchymal scarring or pyelonephritis, and ectopic renal parenchyma. 99m Tc-DMSA binds to metalloproteins in proximal tubular cells and typically localizes to the renal cortex, with minimal excretion. Planar and SPECT images are obtained 2 to 4 hours after IV administration of 99m Tc-DMSA. Altered 99m Tc-DMSA biodistribution has been reported in various conditions, including renal injury, technical issues, infiltrative processes, and hematologic disorders. Here, we present a case of altered biodistribution, with hepatic and splenic radiotracer uptake in the setting of hepatosplenomegaly and hematologic abnormalities concerning for a systemic hematologic disorder/lymphohistiocytosis.