One Minute of EEG Data Provides Sufficient and Reliable Data for Identifying Lewy Body Dementia. (22nd January 2023)

• Record Type: Journal Article
• Authors: Jin, Lucy; Nawaz, Huma; Ono, Kenichiro; Nowell, Justin; Haley, Erik; Berman, Brian D.; Mukhopadhyay, Nitai D.; Barrett, Matthew J.
• Is Part Of: Alzheimer disease and associated disorders. Volume 37:Number 1(2023)
• Page Start: 66
• Page End: 72
• Publication Date: 2023-01-22
• Subjects: Lewy body dementia -- dementia with Lewy bodies -- Parkinson disease dementia -- electroencephalography -- biomarker; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; 616.8305
• DOI: 10.1097/WAD.0000000000000536
• Languages: English
• ISSNs: 0893-0341

Abstract

Abstract : Objective: To determine the minimum duration of electroencephalography (EEG) data necessary to differentiate EEG features of Lewy body dementia (LBD), that is, dementia with Lewy bodies and Parkinson disease dementia, from non-LBD patients, that is, Alzheimer disease and Parkinson disease. Methods: We performed quantitative EEG analysis for 16 LBD and 14 non-LBD patients. After artifact removal, a fast Fourier transform was performed on 90, 60, and thirty 2-second epochs to derive dominant frequency; dominant frequency variability; and dominant frequency prevalence. Results: In LBD patients, there were no significant differences in EEG features derived from 90, 60, and thirty 2-second epochs (all P >0.05). There were no significant differences in EEG features derived from 3 different groups of thirty 2-second epochs (all P >0.05). When analyzing EEG features derived from ninety 2-second epochs, we found that LBD had significantly reduced dominant frequency, reduced dominant frequency variability, and reduced dominant frequency prevalence alpha compared with the non-LBD group (all P <0.05). These same differences were observed between the LBD and non-LBD groups when analyzing thirty 2-second epochs. Conclusions: There were no differences in EEG features derived from 1 minute versus 3 minutes of EEG data, and both durations of EEG data equally differentiated LBD from non-LBD.