Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins. Issue 9 (7th February 2023)

• Record Type: Journal Article
• Authors: Khatri, Vinod; Parshad, Badri; Prasad, Ashok K.; Bhatia, Sumati
• Is Part Of: European journal of organic chemistry. Volume 26:Issue 9(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-07
• Subjects: Carbohydrates -- Drug delivery -- Glycotripod -- Hemagglutinin -- Lectin binder; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202201360
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydrate ligand. Optimized glycotripods are high affinity binders and have been used for delivering drugs or even applied as drug candidates. The selection of the tripodal base scaffold together with the length and flexibility of the linker between the scaffold and sugar residue, as important design parameters are discussed in this review. Abstract : Tripodal glycoconjugates have been widely explored to target trimeric lectins that are present on the surface of hepatic cells, immune cells, and viruses. Glycotripods with stringent binding to trimeric lectins have been investigated as potential drug candidates or for drug targeting. These controlled systems possess high potential in different clinical applications.