New-onset haematoproteinuria in a 63-year-old man with intraperitoneal lymph node enlargement. (23rd February 2016)

• Record Type: Journal Article
• Authors: Minakawa, Akihiro; Hisanaga, Shuichi; Sato, Yuji; Fujimoto, Shouichi
• Is Part Of: BMJ case reports. Volume 2016
• Publication Date: 2016-02-23
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2016-214366
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : A 63-year-old man was referred to our hospital because of renal dysfunction with haematoproteinuria. Intraperitoneal lymph node enlargement was also noted. M protein was not detected by electrophoresis of his serum and urine; however, an increase in the κ/λ ratio was detected by free light-chain assay. Percutaneous kidney biopsy was performed, and the patient was diagnosed with proliferative glomerulonephritis with monoclonal immunoglobulin deposits. Lymph node biopsy showed follicular lymphoma. Urinalysis findings improved after treatment of the lymphoma. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits is rarely considered to be associated with haematological disease. We report a case of lymphoma-associated proliferative glomerulonephritis with monoclonal immunoglobulin deposits with light-chain abnormality detected by free light-chain assay, but not by electrophoresis.