Rare case of radiation-induced trigeminal schwannoma occurring in a long-term glioblastoma multiforme survivor. (11th March 2016)

• Record Type: Journal Article
• Authors: Al Shalchi, Mina; Hussain, Shaila; Giridharan, Selvaraj; Albanese, Erminia
• Is Part Of: BMJ case reports. Volume 2016
• Publication Date: 2016-03-11
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2016-214438
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Glioblastoma multiforme (GBM) is a high-grade primary brain tumour with a notably poor prognosis. Research demonstrates a median survival of just over 1 year following aggressive treatment. Long-term survival is notably rare. Cranial radiotherapy and postexcisional prophylactic treatment is associated with the development of second, histologically distinct tumours in rare cases. Radiation-induced intracranial schwannomas are uncommon, with only a small number of cranial nerve schwannoma cases reported in recent decades. To our knowledge, this is the first reported case of a radiation-induced benign trigeminal schwannoma occurring following long-term survival from glioblastoma. Here we present (1) a rare case of 14-year survival following treatment of a right parietal glioblastoma and the development of a radiation-induced benign trigeminal schwannoma in a 35-year-old man, and (2) a review of radiation-induced schwannoma cases reported in the existing literature.