TopoDB: a novel multifunctional management system for laboratory animal colonies. (18th November 2020)
- Record Type:
- Journal Article
- Title:
- TopoDB: a novel multifunctional management system for laboratory animal colonies. (18th November 2020)
- Main Title:
- TopoDB: a novel multifunctional management system for laboratory animal colonies
- Authors:
- Renschen, Adam
Matsunaga, Atsuko
Oksenberg, Jorge R
Santaniello, Adam
Didonna, Alessandro - Abstract:
- Abstract: Animal models are widely employed in basic research to test mechanistic hypotheses in a complex biological environment as well as to evaluate the therapeutic potential of candidate compounds in preclinical settings. Rodents, and in particular mice, represent the most common in vivo models for their small size, short lifespan and possibility to manipulate their genome. Over time, a typical laboratory will develop a substantial number of inbred strains and transgenic mouse lines, requiring a substantial effort, in both logistic and economic terms, to maintain an animal colony for research purposes and to safeguard the integrity of results. To meet this need, here we present TopoDB, a robust and extensible web-based platform for the rational management of laboratory animals. TopoDB allows an easy tracking of individual animals within the colony and breeding protocols as well as the convenient storage of both genetic and phenotypic data generated in the different experiments. Altogether, these features facilitate and enhance the design of in vivo research, thus reducing the number of necessary animals and the housing costs. In summary, TopoDB represents a novel valuable tool in modern biomedical research. Database URL : https://github.com/UCSF-MS-DCC/TopoDB
- Is Part Of:
- Database. Volume 2020(2020)
- Journal:
- Database
- Issue:
- Volume 2020(2020)
- Issue Display:
- Volume 2020, Issue 2020 (2020)
- Year:
- 2020
- Volume:
- 2020
- Issue:
- 2020
- Issue Sort Value:
- 2020-2020-2020-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-11-18
- Subjects:
- Biology -- Databases -- Periodicals
Bioinformatics -- Periodicals
570.285 - Journal URLs:
- http://database.oxfordjournals.org/ ↗
http://ukcatalogue.oup.com/ ↗ - DOI:
- 10.1093/database/baaa098 ↗
- Languages:
- English
- ISSNs:
- 1758-0463
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 26038.xml