A curated database reveals trends in single-cell transcriptomics. (28th November 2020)

• Record Type: Journal Article
• Authors: Svensson, Valentine; da Veiga Beltrame, Eduardo; Pachter, Lior
• Is Part Of: Database. Volume 2020(2020)
• Publication Date: 2020-11-28
• Subjects: Biology -- Databases -- Periodicals; Bioinformatics -- Periodicals; 570.285
• DOI: 10.1093/database/baaa073
• Languages: English
• ISSNs: 1758-0463

Abstract

Abstract: The more than 1000 single-cell transcriptomics studies that have been published to date constitute a valuable and vast resource for biological discovery. While various 'atlas' projects have collated some of the associated datasets, most questions related to specific tissue types, species or other attributes of studies require identifying papers through manual and challenging literature search. To facilitate discovery with published single-cell transcriptomics data, we have assembled a near exhaustive, manually curated database of single-cell transcriptomics studies with key information: descriptions of the type of data and technologies used, along with descriptors of the biological systems studied. Additionally, the database contains summarized information about analysis in the papers, allowing for analysis of trends in the field. As an example, we show that the number of cell types identified in scRNA-seq studies is proportional to the number of cells analysed. Database URL : www.nxn.se/single-cell-studies/gui